Msl1 Gene Summary [Mouse]
Predicted to enable protein-macromolecule adaptor activity. Involved in chromatin remodeling and positive regulation of DNA-templated transcription. Located in nuclear speck. Part of MSL complex. Is expressed in embryo. Orthologous to human MSL1 (MSL complex subunit 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Msl1 |
| Official Name | male specific lethal 1 [Source:MGI Symbol;Acc:MGI:1921276] |
| Ensembl ID | ENSMUSG00000052915 |
| Bio databases IDs | |
| Aliases | male specific lethal 1 |
| Synonyms | 2810017F12Rik, 4121402D02Rik, 4930463F05Rik, male specific lethal 1, MSL complex subunit 1, RGD1564778 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Msl1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PEHE domain
- protein binding activity, bridging
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Msl1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chromatin remodeling
- positive regulation of transcription, DNA-dependent
Cellular Component
Where in the cell the gene product is active
- nucleus
- MSL complex
- nuclear speck
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- chromatin binding
- protein binding, bridging