Uba2 Gene Summary [Mouse]
Enables SUMO activating enzyme activity. Predicted to be involved in positive regulation of protein sumoylation and protein sumoylation. Part of SUMO activating enzyme complex. Is expressed in several structures, including branchial arch; lens; limb; and neural fold. Orthologous to human UBA2 (ubiquitin like modifier activating enzyme 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Uba2 |
| Official Name | ubiquitin-like modifier activating enzyme 2 [Source:MGI Symbol;Acc:MGI:1858313] |
| Ensembl ID | ENSMUSG00000052997 |
| Bio databases IDs | |
| Aliases | ubiquitin-like modifier activating enzyme 2 |
| Synonyms | ACCES, ARX, HRIHFB2115, LOC100505842, SAE2, UBA1, ubiquitin-like modifier activating enzyme 2, Ubl1a2, UBLE1B |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Uba2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ATP binding
- nuclear localization sequence
- enzyme binding
- SUMO activating enzyme
- transcription factor binding
- Ubiquitin/SUMO-activating enzyme ubiquitin-like domain
- enzyme
- protein binding
- magnesium ion binding
- Ubiquitin-activating enzyme, SCCH domain
- E1_enzyme_family
- protein heterodimerization
- SUMO-activating enzyme subunit 2 C-terminus
Pathways
Biological processes and signaling networks where the Uba2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- breast cancer
- glioma
- glioma formation
- aortic valve calcification
- ACCES syndrome
- vasculogenic mimicry
- renal clear cell adenocarcinoma
- renal clear cell cancer
- hereditary disorder
role in cell
- expression in
- apoptosis
- proliferation
- cell cycle progression
- migration
- autophagy in
- dissociation
- invasion by
- sumoylation in
- polyploidy
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Uba2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein sumoylation
- positive regulation of protein sumoylation
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- SUMO activating enzyme complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- small protein conjugating enzyme binding
- ATP binding
- SUMO binding
- SUMO activating enzyme activity
- protein binding
- protein heterodimerization activity
- small protein activating enzyme binding
- transferase activity