Sae1 Gene Summary [Mouse]
Predicted to enable several functions, including ATP-dependent protein binding activity; SUMO activating enzyme activity; and protein heterodimerization activity. Predicted to be involved in positive regulation of protein sumoylation and protein sumoylation. Part of SUMO activating enzyme complex. Is expressed in genitourinary system and lens. Orthologous to human SAE1 (SUMO1 activating enzyme subunit 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sae1 |
| Official Name | SUMO1 activating enzyme subunit 1 [Source:MGI Symbol;Acc:MGI:1929264] |
| Ensembl ID | ENSMUSG00000052833 |
| Bio databases IDs | |
| Aliases | SUMO1 activating enzyme subunit 1 |
| Synonyms | 2400010M20Rik, 2610044L12Rik, AOS1, D7Ertd177e, HSPC140, SUA1, SUMO1 activating enzyme subunit 1, UBLE1A |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sae1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin activating enzyme
- ThiF family
- ATP-dependent protein binding
- enzyme binding
- SUMO activating enzyme
- enzyme
- protein binding
- enzyme activator activity
- E1_enzyme_family
- protein heterodimerization
Pathways
Biological processes and signaling networks where the Sae1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- multiple sclerosis
- tumorigenesis
role in cell
- proliferation
- growth
- replication in
- apoptosis
- cell cycle progression
- dissociation
- sumoylation in
- polyploidy
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sae1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein sumoylation
- positive regulation of protein sumoylation
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- SUMO activating enzyme complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- SUMO activating enzyme activity
- protein binding
- protein heterodimerization activity
- small protein activating enzyme binding
- ubiquitin activating enzyme activity
- enzyme activator activity
- ATP-dependent protein binding