Rxfp2 Gene Summary [Mouse]
Enables protein-hormone receptor activity. Acts upstream of or within adenylate cyclase-activating G protein-coupled receptor signaling pathway and male gonad development. Predicted to be active in plasma membrane. Is expressed in several structures, including brain; genitourinary system; and peritoneum. Used to study cryptorchidism. Human ortholog(s) of this gene implicated in cryptorchidism. Orthologous to human RXFP2 (relaxin family peptide receptor 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Retained Intron |
| Official Symbol | Rxfp2 |
| Official Name | relaxin/insulin-like family peptide receptor 2 [Source:MGI Symbol;Acc:MGI:2153463] |
| Ensembl ID | ENSMUSG00000053368 |
| Bio databases IDs | |
| Aliases | relaxin/insulin-like family peptide receptor 2 |
| Synonyms | Gpcr, GPR106, GREAT, INSL3R, LGR8, LGR8.1, relaxin family peptide receptor 2, relaxin/insulin-like family peptide receptor 2, Rlf receptor, RXFPR2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rxfp2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- Leucine-rich repeats, outliers
- extracellular domain
- Leucine-rich repeats, typical (most populated) subfamily
- protein phosphatase 1 regulatory subunit 42
- Leucine rich repeat
- Leucine Rich repeats (2 copies)
- seven-transmembrane G protein-coupled receptor superfamily
- polypeptide hormone binding
- hormone binding domain
- leucine-rich repeat
- transmembrane domain
- LDLa
- protein-hormone receptor
- 7 transmembrane receptor (rhodopsin family)
Pathways
Biological processes and signaling networks where the Rxfp2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cilia
- cell surface
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rxfp2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
- oocyte maturation
- male gonad development
- negative regulation of cell proliferation
- negative regulation of apoptotic process
- positive regulation of cAMP-mediated signaling
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
- activation of adenylate cyclase activity
- hormone-mediated signaling pathway
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled peptide receptor activity
- peptide hormone binding
- protein-hormone receptor activity