Insl3 Gene Summary [Mouse]
Predicted to enable G protein-coupled receptor binding activity and protease binding activity. Involved in regulation of male gonad development. Acts upstream of or within in utero embryonic development and male gonad development. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in extracellular space. Is expressed in Leydig cell; cornea; ovary; testis; and trunk. Used to study cryptorchidism. Human ortholog(s) of this gene implicated in cryptorchidism. Orthologous to human INSL3 (insulin like 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Insl3 |
| Official Name | insulin-like 3 [Source:MGI Symbol;Acc:MGI:108427] |
| Ensembl ID | ENSMUSG00000079019 |
| Bio databases IDs | |
| Aliases | insulin-like 3 |
| Synonyms | insulin-like 3, Ley I-L, RLF, RLNL |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Insl3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- insulin receptor binding
- protease binding
- Insulin/IGF/Relaxin family
- Ral binding domain
- G-protein-coupled receptor binding
- IlGF_like
- protein binding
- receptor binding
- growth factor
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- sickle cell anemia
- Hutchinson-Gilford progeria syndrome
- T-cell large granular lymphocytic leukemia
- septic shock
- cardiomyopathy
- cervical cancer
- diabetic nephropathy
- Crohn disease
- adenocarcinoma
role in cell
- proliferation
- apoptosis
- quantity
- expression in
- formation
- maturation
- number
- progression
- migration by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- perinuclear region
- Plasma Membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Insl3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
- positive regulation of wound healing
- oocyte maturation
- male gonad development
- negative regulation of cell proliferation
- spermatogenesis
- negative regulation of apoptotic process
- positive regulation of cell proliferation
- cell-cell signaling
- positive regulation of cAMP-mediated signaling
- positive regulation of epithelial cell migration
Cellular Component
Where in the cell the gene product is active
- extracellular space
- perinuclear region of cytoplasm
- extracellular region
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor binding
- protein binding
- protease binding
- insulin receptor binding
- hormone activity
- receptor binding