KDM3A Gene Summary [Human]
Enables androgen receptor binding activity; histone H3-methyl-lysine-9 demethylase activity; and iron ion binding activity. Involved in several processes, including androgen receptor signaling pathway; formaldehyde biosynthetic process; and histone H3-K9 demethylation. Located in nucleoplasm. Implicated in cervical cancer and colon cancer. Biomarker of Ewing sarcoma; hepatocellular carcinoma; nasopharynx carcinoma; and prostate cancer. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | KDM3A |
| Official Name | lysine demethylase 3A [Source:HGNC Symbol;Acc:HGNC:20815] |
| Ensembl ID | ENSG00000115548 |
| Bio databases IDs | |
| Aliases | lysine demethylase 3A, jumonji C domain-containing histone demethylase 2A |
| Synonyms | 1700105C21Rik, C230043E16Rik, JHDM2A, JHMD2A, JMJD1, JMJD1A, KDM2A, lysine demethylase 3A, lysine (K)-specific demethylase 3A, TGSA, TSGA, Zinc finger protein-putative |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human KDM3A often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- catalytic domain
- 2-oxoglutarate:oxygen oxidoreductase
- transcription cofactor
- androgen receptor binding
- iron ion binding
- chromatin binding
- protein binding
- histone demethylase activity
- RmlC-like cupin superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- non-insulin-dependent diabetes mellitus
- metastasis
- hepatic steatosis
- insulin resistance
- obesity
- weight gain
- colorectal cancer
- hyperlipidemia
- oligozoospermia
role in cell
- expression in
- apoptosis
- proliferation
- morphology
- binding in
- colony formation
- growth
- migration
- G1 phase
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
- acrosome
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human KDM3A gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- spermatid nucleus elongation
- formaldehyde biosynthetic process
- chromatin remodeling
- positive regulation of transcription, DNA-dependent
- regulation of stem cell differentiation
- regulation of stem cell maintenance
- androgen receptor signaling pathway
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
- hormone-mediated signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- membrane
- histone deacetylase complex
- chromatin
- male germ cell nucleus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- chromatin DNA binding
- protein binding
- transcription cofactor activity
- androgen receptor binding
- iron ion binding
- histone demethylase activity (H3-K9 specific)