Tdrd9 Gene Summary [Mouse]
Enables ATP hydrolysis activity. Involved in several processes, including male meiosis I; regulatory ncRNA-mediated gene silencing; and spermatogenesis. Acts upstream of or within transposable element silencing. Located in nucleus and piP-body. Is expressed in germ cell of testis and primary oocyte. Human ortholog(s) of this gene implicated in spermatogenic failure 30. Orthologous to human TDRD9 (tudor domain containing 9). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tdrd9 |
| Official Name | tudor domain containing 9 [Source:MGI Symbol;Acc:MGI:1921941] |
| Ensembl ID | ENSMUSG00000054003 |
| Bio databases IDs | |
| Aliases | tudor domain containing 9 |
| Synonyms | 4930441E05Rik, C14orf75, HIG-1, HLS, NET54, SPGF30, SPNE, tudor domain containing 9 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tdrd9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Helicase associated domain (HA2)
- Tudor domain
- DEAD/DEAH box helicase
- helicase superfamily c-terminal domain
- enzyme
- protein binding
- ATPase
- Helicase conserved C-terminal domain
- Helicase associated domain (HA2) Add an annotation
- N-terminal helicase domain of the DEAD-box helicase superfamily
- DEAD-like helicases superfamily
- Tudor domain superfamily
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- bipolar disorder
- colorectal cancer
- azoospermia
- refractive error
- male infertility
- major depression
- septic shock
- spermatogenic failure 30
regulates
- piRNA
- SNCA
role in cell
- apoptosis
- abnormal morphology
- fertilization
- meiosis I
- meiosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytoplasmic ribonucleoprotein granule
- Nucleus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tdrd9 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- male meiosis
- spermatogenesis
- male meiosis I
- cell differentiation
- fertilization
- piRNA metabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- intracellular
- piP-body
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- RNA binding
- RNA helicase activity
- helicase activity