Rab39 Gene Summary [Mouse]
Predicted to enable GTP binding activity and GTPase activity. Predicted to be involved in phagosome acidification and phagosome-lysosome fusion. Predicted to be located in phagocytic vesicle. Is expressed in brain; brainstem; eye; and testis. Orthologous to human RAB39A (RAB39A, member RAS oncogene family). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rab39 |
| Official Name | RAB39, member RAS oncogene family [Source:MGI Symbol;Acc:MGI:2442855] |
| Ensembl ID | ENSMUSG00000055069 |
| Bio databases IDs | |
| Aliases | RAB39, member RAS oncogene family |
| Synonyms | C230094F14RIK, K28, RAB39, RAB39A, member RAS oncogene family, RAB39, member RAS oncogene family |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rab39 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- small GTP-binding protein domain
- Small GTPase of the Ras superfamily (ill-defined subfamily)
- Ras family
- small monomeric GTPase
- Rab subfamily of small GTPases
- enzyme
- protein binding
- Ras of Complex, Roc, domain of DAPkinase
- Rho (Ras homology) subfamily of Ras-like small GTPases
- P-loop containing Nucleoside Triphosphate Hydrolases
- Ras subfamily of RAS small GTPases
Pathways
Biological processes and signaling networks where the Rab39 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- Plasma Membrane
- cytosol
- Golgi membrane
- lysosome membrane
- phagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rab39 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- vesicle-mediated transport
- autophagy
- protein transport
- Rab protein signal transduction
- phagosome-lysosome fusion
- phagosome acidification
Cellular Component
Where in the cell the gene product is active
- phagocytic vesicle
- cytosol
- phagocytic vesicle membrane
- Golgi membrane
- plasma membrane
- lysosome
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein binding
- GTPase activity