Adh7 Gene Summary [Mouse]
Enables all-trans-retinol dehydrogenase (NAD+) activity. Acts upstream of or within ethanol catabolic process; retinoic acid metabolic process; and retinol metabolic process. Predicted to be located in plasma membrane. Predicted to be active in cytosol. Is expressed in several structures, including branchial arch; embryo mesenchyme; endocrine gland; genitourinary system; and neural fold. Used to study Parkinson's disease. Orthologous to human ADH7 (alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Adh7 |
| Official Name | alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide [Source:MGI Symbol;Acc:MGI:87926] |
| Ensembl ID | ENSMUSG00000055301 |
| Bio databases IDs | |
| Aliases | alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide |
| Synonyms | Adh3, Adh-3e, Adh-3t, ADH4, Adt-1, alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide, alcohol dehydrogenase 7 (class IV), mu or σ polypeptide, Alcohol dehydrogenase class IV mu/sigma chain, Alcohol dehydrogenase class IV mu/σ chain |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Adh7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- alcohol dehydrogenase
- MDR
- retinol binding
- oxidoreductase
- aldehyde oxidase
- Zinc-binding dehydrogenase
- enzyme
- identical protein binding
- NAD or NADH binding
- binding protein
- receptor antagonist activity
- zinc ion binding
- retinol dehydrogenase
- Alcohol dehydrogenase GroES-like domain
Pathways
Biological processes and signaling networks where the Adh7 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- weight loss
- COVID-19
- heroin dependence
- spondylolisthesis
regulates
- retinol
- tretinoin
- geranylgeraniol
- ethanol
- retinoid
- farnesol
- dopamine
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular space
- Plasma Membrane
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Adh7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to ethanol
- response to bacterium
- retinoid metabolic process
- retinol metabolic process
- retinoic acid metabolic process
- fatty acid omega-oxidation
Cellular Component
Where in the cell the gene product is active
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ethanol binding
- zinc ion binding
- retinol dehydrogenase activity
- omega-hydroxydecanoate dehydrogenase activity
- receptor antagonist activity
- aldehyde oxidase activity
- retinol binding
- alcohol dehydrogenase (NAD) activity
- alcohol dehydrogenase activity, zinc-dependent