Tns1 Gene Summary [Mouse]
Predicted to enable actin binding activity. Acts upstream of or within cell-substrate junction assembly and fibroblast migration. Located in focal adhesion. Is expressed in several structures, including future brain; gut; heart; metanephros; and yolk sac. Orthologous to human TNS1 (tensin 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tns1 |
| Official Name | tensin 1 [Source:MGI Symbol;Acc:MGI:104552] |
| Ensembl ID | ENSMUSG00000055322 |
| Bio databases IDs | |
| Aliases | tensin 1 |
| Synonyms | 1110018I21Rik, 1200014E20Rik, E030018G17Rik, E030037J05RIK, LOC102723375, MST091, MST122, MST127, MSTP091, MSTP122, MSTP127, MXRA6, PPP1R155, Tensin 1, TNS |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tns1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Protein tyrosine phosphatase, catalytic domain, undefined specificity
- protein kinase C conserved region 1 (C1 domain) superfamily
- actin binding
- C2 domain of PTEN tumour-suppressor protein
- Src homology 2 (SH2) domain
- protein binding
- Pleckstrin homology-like domain
- PTP_DSP_cys
- Protein tyrosine phosphatase, catalytic domain motif
Pathways
Biological processes and signaling networks where the Tns1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chronic obstructive pulmonary disease
- non-insulin-dependent diabetes mellitus
- small cell lung cancer
- pemphigus vulgaris
- colorectal cancer
- coronary artery disease
- ventral hernia
- diverticular disease
- Waldenström macroglobulinemia
- breast carcinoma
role in cell
- phosphorylation in
- migration
- adhesion
- development
- polarization
- morphology
- fibrillogenesis in
- invasion
- cell spreading
- recruitment
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell junction
- Cytoplasm
- focal adhesions
- cytosol
- apical cytoplasm
- basal membrane
- fibrils
- cytoskeletal fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tns1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell-substrate junction assembly
- fibroblast migration
Cellular Component
Where in the cell the gene product is active
- cytoskeleton
- focal adhesion
- cytoplasm
- cell surface
Molecular Function
What the gene product does at the molecular level
- phosphoprotein phosphatase activity
- RNA binding
- protein binding
- actin binding
- metal ion binding