Adgrf5 Gene Summary [Mouse]
Predicted to enable G protein-coupled receptor activity. Involved in surfactant homeostasis. Acts upstream of or within several processes, including glomerular filtration; negative regulation of macrophage activation; and pharyngeal arch artery morphogenesis. Located in apical part of cell. Is expressed in several structures, including cardiovascular system; genitourinary system; gut; hemolymphoid system; and respiratory system. Orthologous to human ADGRF5 (adhesion G protein-coupled receptor F5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Adgrf5 |
| Official Name | adhesion G protein-coupled receptor F5 [Source:MGI Symbol;Acc:MGI:2182928] |
| Ensembl ID | ENSMUSG00000056492 |
| Bio databases IDs | |
| Aliases | adhesion G protein-coupled receptor F5 |
| Synonyms | 8430401C09RIK, 9330185D23, adhesion G protein-coupled receptor F5, GPR116, Gprhep, G protein-coupled heptahelical receptor ig-hepta, IG-HEPTA, KIAA0758, KPG 001, mKIAA0758 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Adgrf5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- 7 transmembrane receptor (Secretin family)
- immunoglobulin domain
- Immunoglobulin like
- SEA domain
- Immunoglobulin I-set domain
- GPCR proteolysis site, GPS, motif
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the Adgrf5 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- idiopathic scoliosis
- metastasis
- tachypnea
- preeclampsia
- organismal death
- colorectal cancer
- osteoarthropathy
- dyspnea
- alcoholism
phenotypes
- decreased bone mineral content
- decreased bone mineral density
- decreased circulating HDL cholesterol level
- decreased circulating cholesterol level
- decreased hematocrit
- decreased hemoglobin content
- decreased leukocyte cell number
- decreased lymphocyte cell number
- decreased mean corpuscular hemoglobin
- decreased mean corpuscular hemoglobin concentration
- decreased mean corpuscular volume
- decreased startle reflex
- increased circulating bilirubin level
- increased grip strength
- increased heart weight
- short tibia
- abnormal alveolar macrophage morphology
- abnormal bone mineral density
- abnormal bone mineralization
- abnormal circulating cholesterol level
- abnormal fasting circulating glucose level
- abnormal heart weight
- abnormal hemoglobin content
- abnormal leukocyte cell number
- abnormal lipid level
- abnormal lung morphology
- abnormal lymphocyte cell number
- abnormal mean corpuscular hemoglobin
- abnormal mean corpuscular volume
- abnormal pulmonary alveolus morphology
- abnormal respiration
- abnormal respiratory system physiology
- abnormal startle reflex
- abnormal surfactant composition
- abnormal surfactant physiology
- abnormal type II pneumocyte morphology
- decreased body weight
- emphysema
- increased alveolar lamellar body number
- increased cholesterol level
- increased circulating glucose level
- increased lung weight
- increased macrophage cell number
- increased macrophage derived foam cell number
- increased surfactant secretion
- increased type II pneumocyte number
- premature death
- pulmonary alveolar proteinosis
- respiratory distress
- tachypnea
role in cell
- migration
- expression in
- phosphorylation in
- differentiation
- accumulation in
- activation in
- production in
- number
- formation
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- apical compartment
- cellular membrane
- cytoplasmic vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Adgrf5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- G-protein coupled receptor signaling pathway
- glomerular filtration
- phospholipid biosynthetic process
- energy reserve metabolic process
- cell surface receptor signaling pathway
- erythrocyte development
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
- fat cell differentiation
- macrophage activation
- surfactant homeostasis
- positive regulation of phospholipid biosynthetic process
- negative regulation of macrophage activation
- glucose homeostasis
- regulation of lipid metabolic process
Cellular Component
Where in the cell the gene product is active
- apical part of cell
- membrane
- cytoplasmic vesicle
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- protein binding