Saa2 Gene Summary [Mouse]

Predicted to enable G protein-coupled receptor binding activity. Involved in response to stilbenoid. Predicted to be located in cytoplasmic microtubule. Predicted to be part of high-density lipoprotein particle. Is expressed in adrenal gland; liver; and metanephros. Orthologous to human SAA1 (serum amyloid A1) and SAA2 (serum amyloid A2). [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Protein Coding
Official Symbol
Saa2
Official Name
serum amyloid A 2 [Source:MGI Symbol;Acc:MGI:98222]
Ensembl ID
ENSMUSG00000057465
Bio databases IDs NCBI: 20209 Ensembl: ENSMUSG00000057465
Aliases serum amyloid A 2
Synonyms Saa1, Saa2, serum amyloid A 1, serum amyloid A 2
Species
Mouse, Mus musculus

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Saa2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • G-protein-coupled receptor binding
  • Serum amyloid A protein
  • protein binding

Pathways

Biological processes and signaling networks where the Saa2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
  • heparin
  • heparan sulfate
  • MHC II (complex)
  • Congo Red
  • LAMA1
  • IL12B
  • Saa1/Saa2
disease
  • albuminuria
  • pancreatic ductal adenocarcinoma
  • pancreatic epithelial cancer
  • ductal pancreatic cancer
  • rheumatoid arthritis
  • atelectasis
  • cardiac fibrosis
  • renal fibrosis
  • Staphylococcus aureus pneumonia
  • stenosis
regulated by
  • beta-naphthoflavone
  • CFTR
  • IL4
  • CEBPB
  • 1,2-dithiole-3-thione
  • RARB
  • IL1B
  • Escherichia coli O6
  • heparin
  • dexamethasone
regulates
role in cell
  • survival
  • expression in
  • phosphorylation in
  • migration
  • apoptosis
  • disruption
  • disruption in
  • activation
  • formation
  • quantity

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • Extracellular Space
  • cytoplasmic microtubule

Gene-Specific Assays for Results You Can Trust

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