Lmcd1 Gene Summary [Mouse]
Enables transcription corepressor activity. Involved in positive regulation of calcineurin-NFAT signaling cascade and regulation of cardiac muscle hypertrophy. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and lung. Orthologous to human LMCD1 (LIM and cysteine rich domains 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lmcd1 |
| Official Name | LIM and cysteine-rich domains 1 [Source:MGI Symbol;Acc:MGI:1353635] |
| Ensembl ID | ENSMUSG00000057604 |
| Bio databases IDs | |
| Aliases | LIM and cysteine-rich domains 1 |
| Synonyms | dyxin, LIM and cysteine-rich domains 1, LIMD1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lmcd1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- LIM is a small protein-protein interaction domain, containing two zinc fingers
- transcription co-repressor
- PET domain
- protein binding
- cysteine rich domain
- PET (Prickle Espinas Testin)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung metastasis
- epithelial cancer
- hepatocellular carcinoma
- liver cancer
- narcolepsy with cataplexy
- Duchenne muscular dystrophy
- Huntington disease
- myotonic dystrophy
- peripheral arterial disease
- diverticular disease
role in cell
- expression in
- proliferation
- activation in
- accumulation
- migration
- accumulation in
- differentiation
- assembly
- assembly in
- hypertrophy
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- nuclear fraction
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lmcd1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- regulation of cardiac muscle hypertrophy
- positive regulation of calcineurin-NFAT signaling cascade
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- transcription corepressor activity