Csf2ra Gene Summary [Mouse]
Predicted to enable cytokine receptor activity. Predicted to be involved in cell surface receptor signaling pathway via JAK-STAT; granulocyte-macrophage colony-stimulating factor signaling pathway; and positive regulation of leukocyte proliferation. Predicted to be located in membrane. Predicted to be part of granulocyte macrophage colony-stimulating factor receptor complex. Is expressed in early conceptus; female reproductive system; and liver. Used to study pulmonary alveolar proteinosis. Human ortholog(s) of this gene implicated in pulmonary alveolar proteinosis. Orthologous to human CSF2RA (colony stimulating factor 2 receptor subunit alpha). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Csf2ra |
| Official Name | colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) [Source:MGI Symbol;Acc:MGI:1339754] |
| Ensembl ID | ENSMUSG00000059326 |
| Bio databases IDs | |
| Aliases | colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) |
| Synonyms | CD116, colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage), colony stimulating factor 2 receptor subunit alpha, colony stimulating factor 2 receptor subunit α, colony stimulating factor 2 receptor, α, low-affinity (granulocyte-macrophage), Csfgmra, GM-CSFR, GM-CSF-Ra, GM-CSF receptor α |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Csf2ra often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- IL-3 receptor alpha chain N-terminal domain
- cytoplasmic domain
- FN3
- ectodomain
- proline rich domain
Pathways
Biological processes and signaling networks where the Csf2ra gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane