Polr2e Gene Summary [Mouse]
Predicted to enable DNA binding activity. Predicted to contribute to DNA-directed RNA polymerase activity. Predicted to be involved in tRNA transcription by RNA polymerase III; transcription by RNA polymerase II; and transcription elongation by RNA polymerase I. Predicted to be located in nucleoplasm. Predicted to be part of RPAP3/R2TP/prefoldin-like complex and nuclear DNA-directed RNA polymerase complex. Is expressed in several structures, including branchial arch; embryo mesenchyme; maxillary process; nervous system; and sensory organ. Orthologous to human POLR2E (RNA polymerase II, I and III subunit E). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Polr2e |
| Official Name | polymerase (RNA) II (DNA directed) polypeptide E [Source:MGI Symbol;Acc:MGI:1913670] |
| Ensembl ID | ENSMUSG00000004667 |
| Bio databases IDs | |
| Aliases | polymerase (RNA) II (DNA directed) polypeptide E |
| Synonyms | 2410021N14Rik, hRPB25, hsRPB5, LOC687055, polymerase (RNA) II (DNA directed) polypeptide E, RNA polymerase ii 23 kd subunit, RNA polymerase II, I and III subunit E, RPABC1, RPB5, XAP4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Polr2e often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase Rpb5, C-terminal domain
- DNA-directed RNA polymerase
- PLN03111
- RNA polymerase Rpb5, N-terminal domain
- enzyme
- protein binding
Pathways
Biological processes and signaling networks where the Polr2e gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- detergent resistant lipid raft fraction
- cytosol
- nucleoplasm
- nucleoli
- interchromatin granule clusters
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Polr2e gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transcription elongation from RNA polymerase I promoter
- transcription from RNA polymerase II promoter
- protein stabilization
- tRNA transcription from RNA polymerase III promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- DNA-directed RNA polymerase I complex
- cytosol
- DNA-directed RNA polymerase III complex
- nucleoplasm
- DNA-directed RNA polymerase II, core complex
Molecular Function
What the gene product does at the molecular level
- DNA binding
- RNA polymerase III activity
- RNA polymerase II activity
- protein binding
- RNA polymerase I activity
- DNA-directed RNA polymerase activity