Adgrg3 Gene Summary [Mouse]
Predicted to enable G protein-coupled receptor activity. Involved in B cell differentiation; negative regulation of CREB transcription factor activity; and negative regulation of non-canonical NF-kappaB signal transduction. Predicted to be active in plasma membrane. Orthologous to human ADGRG3 (adhesion G protein-coupled receptor G3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Adgrg3 |
| Official Name | adhesion G protein-coupled receptor G3 [Source:MGI Symbol;Acc:MGI:1859670] |
| Ensembl ID | ENSMUSG00000060470 |
| Bio databases IDs | |
| Aliases | adhesion G protein-coupled receptor G3 |
| Synonyms | A030001G24Rik, adhesion G protein-coupled receptor G3, GPR97, Pb1, PB99, PGR26 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Adgrg3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- 7 transmembrane receptor (Secretin family)
- GPCR proteolysis site, GPS, motif
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the Adgrg3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- septic shock
role in cell
- phosphorylation in
- apoptosis
- number
- migration
- abnormal morphology
- adhesion
- differentiation
- activation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- specific granule membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Adgrg3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- B cell differentiation
- G-protein coupled receptor signaling pathway
- negative regulation of CREB transcription factor activity
- cell surface receptor signaling pathway
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
- regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- membrane
- plasma membrane
- specific granule membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- protein binding