Atp6v0b Gene Summary [Mouse]
Predicted to enable P-type proton-exporting transporter activity. Predicted to act upstream of or within proton transmembrane transport. Located in endosome and membrane. Part of proton-transporting V-type ATPase complex. Is expressed in several structures, including genitourinary system; liver; nervous system; nose; and spleen. Orthologous to human ATP6V0B (ATPase H+ transporting V0 subunit b). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Atp6v0b |
| Official Name | ATPase, H+ transporting, lysosomal V0 subunit B [Source:MGI Symbol;Acc:MGI:1890510] |
| Ensembl ID | ENSMUSG00000033379 |
| Bio databases IDs | |
| Aliases | ATPase, H+ transporting, lysosomal V0 subunit B |
| Synonyms | 2310024H13Rik, ATP6F, Atp6v0bl1, Atp6v0b predicted, ATPASE, H+ TRANSPORTING, LYSOSOMAL 21 KDA, ATPase, H+ transporting, lysosomal V0 subunit B, ATPase H+ transporting V0 subunit B, HATPL, VMA16 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Atp6v0b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ATP synthase subunit C
- H+-transporting two-sector ATPase
- ATP synthase, membrane-bound Fo/Vo/Ao complexes, subunit c
- hydrogen-transporting ATPase activity, rotational mechanism
- protein binding
- H+-exporting ATPase
- transporter
Pathways
Biological processes and signaling networks where the Atp6v0b gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- endosomes
- lysosome membrane
- endosomal membrane
- phagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Atp6v0b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- intracellular pH reduction
- endosomal lumen acidification
- lysosomal lumen acidification
- regulation of macroautophagy
- vacuolar acidification
Cellular Component
Where in the cell the gene product is active
- vacuolar proton-transporting V-type ATPase, V0 domain
- proton-transporting V-type ATPase complex
- membrane
- phagocytic vesicle membrane
- endosome membrane
- Golgi membrane
- lysosomal membrane
- plasma membrane
- clathrin coated vesicle membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- proton-transporting ATPase activity, rotational mechanism