Wasf2 Gene Summary [Mouse]
Predicted to enable Arp2/3 complex binding activity; SH3 domain binding activity; and protein kinase A regulatory subunit binding activity. Involved in postsynaptic actin cytoskeleton organization. Acts upstream of or within several processes, including Rac protein signal transduction; lamellipodium organization; and megakaryocyte development. Located in several cellular components, including early endosome; lamellipodium; and ruffle. Part of SCAR complex. Is active in synapse. Is expressed in several structures, including central nervous system; dorsal aorta; genitourinary system; heart; and yolk sac. Orthologous to human WASF2 (WASP family member 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Wasf2 |
| Official Name | WASP family, member 2 [Source:MGI Symbol;Acc:MGI:1098641] |
| Ensembl ID | ENSMUSG00000028868 |
| Bio databases IDs | |
| Aliases | WASP family, member 2 |
| Synonyms | D4Ertd13e, dJ393P12.2, IMD2, SCAR2, WASF4, WASP family member 2, WASP family, member 2, WAVE2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Wasf2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Wiskott Aldrich syndrome homology region 2
- protein kinase A binding
- VCA domain
- protein binding
- polyproline motif
- proline rich domain
- SH3-domain binding
- WCA region
- WH2 motif
- phosphorylation site
- Scar/WAVE homology domain
- verprolin homology domain
- WA domain
- WAVE homology domain
- actin binding
Pathways
Biological processes and signaling networks where the Wasf2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- edema
- cancer
- oral squamous cell carcinoma
- squamous cell cancer of the oral cavity
- lymphomagenesis
- B cell cancer
- bleeding
- growth failure
- hypoplasia
- hematological neoplasia
role in cell
- morphology
- proliferation
- differentiation
- production
- migration
- activation in
- accumulation
- development
- ruffling
- formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- ruffle
- Cytoplasm
- intracellular space
- cellular membrane
- actin cytoskeleton
- Nucleus
- intercellular junctions
- cytosol
- membrane ruffles
- plasma membrane projections
- synapse
- early endosomes
- filopodia
- cell membrane leading edge
- lamellipodia
- macropinosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Wasf2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- Rac protein signal transduction
- positive regulation of lamellipodium assembly
- adenylate cyclase-modulating G-protein coupled receptor signaling pathway
- endocytosis
- negative regulation of stress fiber assembly
- ameboidal cell migration
- angiogenesis
- lamellipodium morphogenesis
- megakaryocyte development
- lamellipodium assembly
- positive regulation of Arp2/3 complex-mediated actin nucleation
- actin filament-based movement
- actin cytoskeleton organization
Cellular Component
Where in the cell the gene product is active
- SCAR complex
- early endosome
- extracellular vesicular exosome
- cell-cell junction
- actin cytoskeleton
- ruffle
- cytosol
- macromolecular complex
- synapse
- basolateral plasma membrane
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- protein binding
- actin binding
- cadherin binding
- protein kinase A regulatory subunit binding
- SH3 domain binding
- protein kinase A binding
- Arp2/3 complex binding