Itgb1bp1 Gene Summary [Mouse]
Enables protein kinase binding activity. Involved in several processes, including integrin activation; positive regulation of stress fiber assembly; and regulation of cell-substrate adhesion. Located in several cellular components, including cytoskeleton; lamellipodium; and ruffle. Is expressed in left lung and right lung. Orthologous to human ITGB1BP1 (integrin subunit beta 1 binding protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Itgb1bp1 |
| Official Name | integrin beta 1 binding protein 1 [Source:MGI Symbol;Acc:MGI:1306802] |
| Ensembl ID | ENSMUSG00000062352 |
| Bio databases IDs | |
| Aliases | integrin beta 1 binding protein 1 |
| Synonyms | AI449260, Bodenin, ICAP1, ICAP-1A, ICAP-1alpha, ICAP-1B, integrin beta 1 binding protein 1, integrin subunit beta 1 binding protein 1, integrin subunit β 1 binding protein 1, integrin β 1 binding protein 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Itgb1bp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase binding
- GDP-dissociation inhibitor
- protein kinase binding
- integrin binding
- protein binding
- Pleckstrin homology-like domain
- Beta-1 integrin binding protein
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- hypoplasia
- exophthalmos
role in cell
- expression in
- activation in
- proliferation
- phosphorylation in
- accumulation in
- molecular cleavage in
- migration
- survival
- assembly
- dissociation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- plasma membrane fraction
- ruffle
- cytoskeleton
- Cytoplasm
- cell periphery
- perinuclear region
- Nucleus
- centrosome
- cytosol
- nucleoplasm
- nuclear bodies
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Itgb1bp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of protein targeting to membrane
- positive regulation of protein targeting to membrane
- negative regulation of cell proliferation
- positive regulation of cell proliferation
- blood vessel endothelial cell proliferation involved in sprouting angiogenesis
- positive regulation of transcription from RNA polymerase II promoter
- negative regulation of protein binding
- negative regulation of cell migration involved in sprouting angiogenesis
- positive regulation of Notch signaling pathway
- negative regulation of protein kinase activity
- integrin-mediated signaling pathway
- negative regulation of cell adhesion involved in substrate-bound cell migration
- positive regulation of cell division
- cell migration
- positive regulation of endothelial cell migration
- activation of protein kinase B activity
- intracellular signal transduction
- biomineral tissue development
- cell-matrix adhesion
- regulation of integrin-mediated signaling pathway
- negative regulation of substrate adhesion-dependent cell spreading
- cellular response to fibroblast growth factor stimulus
- receptor clustering
- negative regulation of focal adhesion assembly
- regulation of cell adhesion mediated by integrin
- positive regulation of focal adhesion assembly
- Notch signaling pathway
- myoblast migration
- positive regulation of stress fiber assembly
- negative regulation of ERK1 and ERK2 cascade
- regulation of GTPase activity
- cell differentiation
- negative regulation of fibroblast migration
- cellular response to vascular endothelial growth factor stimulus
- tube formation
- protein localization in plasma membrane
- positive regulation of protein kinase B signaling cascade
- integrin activation
Cellular Component
Where in the cell the gene product is active
- nuclear body
- centriolar satellite
- plasma membrane
- nucleoplasm
- nucleus
- perinuclear region of cytoplasm
- cytoskeleton
- focal adhesion
- cytoplasm
- membrane
- ruffle
- cytosol
- cell periphery
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- GDP-dissociation inhibitor activity
- protein binding
- integrin binding