Bcl9l Gene Summary [Mouse]
Enables beta-catenin binding activity. Acts upstream of or within several processes, including canonical Wnt signaling pathway; positive regulation of transcription by RNA polymerase II; and skeletal muscle cell differentiation. Located in nucleus. Is expressed in several structures, including respiratory system cartilage; sensory organ; skeleton; trunk unsegmented mesenchyme; and vibrissa. Orthologous to human BCL9L (BCL9 like). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Bcl9l |
| Official Name | B cell CLL/lymphoma 9-like [Source:MGI Symbol;Acc:MGI:1933114] |
| Ensembl ID | ENSMUSG00000063382 |
| Bio databases IDs | |
| Aliases | B cell CLL/lymphoma 9-like |
| Synonyms | B9L, BC003321, B cell CLL/lymphoma 9-like, BCL9-2, BCL9 like, DLNB11 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Bcl9l often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- beta-catenin binding
- B-cell lymphoma 9 protein
- protein binding
- HD domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- colorectal cancer
- organismal death
- chronic lymphocytic leukemia
- metastasis
- pneumonia
- septic shock
regulates
- DNA endogenous promoter
- DNA promoter
- RNA polymerase II
- CTNNB1
role in cell
- cellular infiltration by
- differentiation
- morphogenesis
- transformation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- fibrillar center
- Nucleus
- nucleoplasm
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Bcl9l gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of epithelial to mesenchymal transition
- regulation of cell morphogenesis
- skeletal muscle cell differentiation
- somatic stem cell maintenance
- myoblast differentiation
- canonical Wnt receptor signaling pathway
- transcription from RNA polymerase II promoter
- positive regulation of transcription from RNA polymerase II promoter
- negative regulation of transforming growth factor beta receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- fibrillar center
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- transcription coactivator activity
- beta-catenin binding