Unc5d Gene Summary [Mouse]
Predicted to enable netrin receptor activity. Acts upstream of or within axon guidance; pyramidal neuron differentiation; and regulation of neuron migration. Located in cell surface. Is expressed in several structures, including brain; female reproductive system; jaw; limb; and sensory organ. Orthologous to human UNC5D (unc-5 netrin receptor D). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Unc5d |
| Official Name | unc-5 netrin receptor D [Source:MGI Symbol;Acc:MGI:2389364] |
| Ensembl ID | ENSMUSG00000063626 |
| Bio databases IDs | |
| Aliases | unc-5 netrin receptor D |
| Synonyms | D930029E11RIK, mKIAA1777, PRO34692, Unc5h4, unc-5 netrin receptor D |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Unc5d often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Thrombospondin type 1 repeats
- Death domain
- extracellular domain
- Thrombospondin type 1 domain
- immunoglobulin domain
- Immunoglobulin like
- Immunoglobulin I-set domain
- protein binding
- Death Domain Superfamily of protein-protein interaction domains
- UPA domain
- ZU5 domain
Pathways
Biological processes and signaling networks where the Unc5d gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- depressive disorder
- insomnia
- idiopathic scoliosis
- COVID-19
- uterine leiomyoma
- leiomyomatosis
- diabetic nephropathy
- neuropathy
- neuroticism
role in cell
- differentiation
- migration
- migration by
- distribution
- guidance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Unc5d gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- pyramidal neuron differentiation
- apoptotic process
- axon guidance
- netrin-activated signaling pathway
- regulation of neuron migration
Cellular Component
Where in the cell the gene product is active
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- netrin receptor activity