Flrt2 Gene Summary [Mouse]
Enables chemorepellent activity and fibroblast growth factor receptor binding activity. Involved in basement membrane organization; cell adhesion involved in heart morphogenesis; and fibroblast growth factor receptor signaling pathway. Acts upstream of or within axon guidance; positive regulation of synapse assembly; and regulation of neuron migration. Located in cell-cell junction; extracellular space; and plasma membrane. Is active in glutamatergic synapse; postsynaptic membrane; and presynaptic membrane. Colocalizes with focal adhesion. Is expressed in several structures, including branchial arch; central nervous system; embryo mesenchyme; heart; and sensory organ. Orthologous to human FLRT2 (fibronectin leucine rich transmembrane protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Flrt2 |
| Official Name | fibronectin leucine rich transmembrane protein 2 [Source:MGI Symbol;Acc:MGI:3603594] |
| Ensembl ID | ENSMUSG00000047414 |
| Bio databases IDs | |
| Aliases | fibronectin leucine rich transmembrane protein 2 |
| Synonyms | fibronectin leucine rich transmembrane protein 2, KIAA0405, LOC100506718, LOC102724348, LOC107984662, LOC124907389 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Flrt2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Leucine-rich repeats, outliers
- Leucine-rich repeats, typical (most populated) subfamily
- extracellular domain
- protein phosphatase 1 regulatory subunit 42
- chemorepellant
- Leucine rich repeat
- Leucine rich repeat C-terminal domain
- BspA type Leucine rich repeat region (6 copies)
- protein binding
- fibroblast growth factor receptor binding
- FN3
- Leucine rich repeat N-terminal domain
- cytosolic tail domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- edema
- colon epithelial cancer
- epithelial cancer
- liver cancer
- invasive breast carcinoma
- breast carcinoma
- invasive breast cancer
- keratocystic odontogenic tumor
- keratocystic odontogenic tumors
role in cell
- expression in
- differentiation
- phosphorylation in
- phagocytosis by
- migration
- guidance
- cell-cell adhesion
- organization
- migration by
- distribution
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- Extracellular Space
- cellular membrane
- focal adhesions
- intercellular junctions
- presynaptic membrane
- postsynaptic membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Flrt2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell adhesion involved in heart morphogenesis
- negative chemotaxis
- heart morphogenesis
- fibroblast growth factor receptor signaling pathway
- basement membrane organization
- axon guidance
- positive regulation of synapse assembly
- regulation of neuron migration
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- extracellular space
- cell-cell junction
- extracellular vesicular exosome
- focal adhesion
- synapse
- extracellular matrix
- neuron projection
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- chemorepellent activity
- protein binding, bridging
- fibroblast growth factor receptor binding