Msi2 Gene Summary [Mouse]
Enables poly(U) RNA binding activity. Involved in stem cell development. Located in cytoplasm. Is expressed in several structures, including central nervous system; gonad; hair follicle; limb bud; and sensory organ. Orthologous to human MSI2 (musashi RNA binding protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Msi2 |
| Official Name | musashi RNA-binding protein 2 [Source:MGI Symbol;Acc:MGI:1923876] |
| Ensembl ID | ENSMUSG00000069769 |
| Bio databases IDs | |
| Aliases | musashi RNA-binding protein 2 |
| Synonyms | 1700105C15Rik, FLJ36569, LOC100038945, LOC100504473, MSI2H, musashi RNA-binding protein 2, RGD1560397 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Msi2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA recognition motif (RRM) superfamily
- RNA recognition motif
- protein binding
- single-stranded RNA binding
- identical protein binding
- poly(U) binding protein
Pathways
Biological processes and signaling networks where the Msi2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- neoplasia
- epithelial cancer
- cancer
- metastasis
- organismal death
- schizophrenia
- androgenic alopecia
- renal clear cell adenocarcinoma
- renal clear cell cancer
role in cell
- activation in
- apoptosis
- expression in
- proliferation
- growth
- cell death
- formation
- invasion
- number
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- polyribosome fractions
- intracellular membrane-bounded organelle
- Nucleus
- polysomes
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Msi2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of translation
- central nervous system development
- stem cell development
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- intracellular membrane-bounded organelle
- cytosol
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- RNA binding
- protein binding
- mRNA binding
- poly(U) RNA binding