Hilpda Gene Summary [Mouse]
Predicted to enable signaling receptor binding activity. Predicted to be involved in several processes, including autocrine signaling; positive regulation of cytokine production; and positive regulation of lipid storage. Predicted to be located in several cellular components, including cell surface; nucleoplasm; and secretory granule. Predicted to be active in lipid droplet. Is expressed in brain and brain vascular element. Human ortholog(s) of this gene implicated in colorectal cancer and hepatocellular carcinoma. Orthologous to human HILPDA (hypoxia inducible lipid droplet associated). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hilpda |
| Official Name | hypoxia inducible lipid droplet associated [Source:MGI Symbol;Acc:MGI:1916823] |
| Ensembl ID | ENSMUSG00000043421 |
| Bio databases IDs | |
| Aliases | hypoxia inducible lipid droplet associated |
| Synonyms | 2310016C08Rik, C7orf68, HIG-2, Hypoxia-induced gene 2, hypoxia inducible lipid droplet-associated |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hilpda often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Hypoxia-inducible lipid droplet-associated
- protein binding
- receptor binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- hepatocellular carcinoma
- liver cancer
- renal clear cell adenocarcinoma
- renal clear cell cancer
- bladder cancer
- oral submucous fibrosis
role in cell
- expression in
- invasion by
- proliferation
- phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell surface
- Extracellular Space
- lipid droplets
- cytosol
- nucleoplasm
- secretory granules
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Hilpda gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of cell proliferation
- cellular response to hypoxia
- positive regulation of cytokine production
- positive regulation of lipid storage
- autocrine signaling
Cellular Component
Where in the cell the gene product is active
- lipid particle
- extracellular space
- secretory granule
- membrane
- cytosol
- nucleoplasm
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein binding
- receptor binding