Ptprt Gene Summary [Mouse]
Enables several functions, including alpha-catenin binding activity; beta-catenin binding activity; and delta-catenin binding activity. Acts upstream of or within protein dephosphorylation. Predicted to be located in cell surface and plasma membrane. Predicted to be active in glutamatergic synapse and postsynaptic density membrane. Is expressed in several structures, including alimentary system; nervous system; respiratory system; sensory organ; and skeleton. Human ortholog(s) of this gene implicated in colorectal cancer and esophagus squamous cell carcinoma. Orthologous to human PTPRT (protein tyrosine phosphatase receptor type T). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ptprt |
| Official Name | protein tyrosine phosphatase, receptor type, T [Source:MGI Symbol;Acc:MGI:1321152] |
| Ensembl ID | ENSMUSG00000053141 |
| Bio databases IDs | |
| Aliases | protein tyrosine phosphatase, receptor type, T |
| Synonyms | LOC680887, LOC680897, mKIAA0283, mRPTPrho, protein tyrosine phosphatase receptor type T, protein tyrosine phosphatase, receptor type, T, RPTPmam4, RPTP-rfo, RPTP-rho, R-PTP-T |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ptprt often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- alpha-catenin binding
- protein-tyrosine-phoshatase
- Protein tyrosine phosphatase, catalytic domain
- transcription factor binding
- PTP_DSP_cys
- Fibronectin type 3 domain
- Protein tyrosine phosphatase, catalytic domain motif
- Protein tyrosine phosphatase, catalytic domain, undefined specificity
- Protein-tyrosine phosphatase
- phosphatase
- intracellular domain
- cadherin binding
- MAM domain, meprin/A5/mu
- thiolester hydrolase
- beta-catenin binding
- actinin binding
- immunoglobulin domain
- protein phosphatase binding
- protein binding
- phosphatase domain
- Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
- gamma-catenin binding
- FN3
- transmembrane receptor protein tyrosine phosphatase
- protein homodimerization
Pathways
Biological processes and signaling networks where the Ptprt gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- acute myeloid leukemia
- venous thromboembolism
- COVID-19
- epithelial neoplasia
- benign neoplasia
- neoplasia
- head and neck squamous cell carcinoma
- head and neck squamous cell cancer
- breast cancer
- androgenic alopecia
role in cell
- accumulation in
- cell death
- expression in
- phosphorylation in
- migration
- proliferation
- survival
- adhesion
- organization
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- pH resistant lipid raft fraction
- glutaminergic synapse
- cell surface
- cellular membrane
- synaptic membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ptprt gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to interleukin-6
- regulation of synapse organization
- signal transduction
- protein dephosphorylation
- transmembrane receptor protein tyrosine kinase signaling pathway
- cell adhesion
- homophilic cell adhesion
- peptidyl-tyrosine dephosphorylation
- negative regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- membrane
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein phosphatase binding
- protein homodimerization activity
- alpha-actinin binding
- beta-catenin binding
- transmembrane receptor protein tyrosine phosphatase activity
- alpha-catenin binding
- delta-catenin binding
- gamma-catenin binding
- protein binding
- protein tyrosine phosphatase activity
- cadherin binding
- thiolester hydrolase activity