Ppp2r5a Gene Summary [Mouse]
Predicted to enable kinase binding activity; phosphoprotein phosphatase activity; and protein phosphatase activator activity. Predicted to be involved in negative regulation of protein localization to plasma membrane and protein dephosphorylation. Located in M band and Z disc. Is expressed in several structures, including brain; gonad; hemolymphoid system gland; liver; and neural retina. Orthologous to human PPP2R5A (protein phosphatase 2 regulatory subunit B'alpha). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ppp2r5a |
| Official Name | protein phosphatase 2, regulatory subunit B', alpha [Source:MGI Symbol;Acc:MGI:2388479] |
| Ensembl ID | ENSMUSG00000026626 |
| Bio databases IDs | |
| Aliases | protein phosphatase 2, regulatory subunit B', alpha |
| Synonyms | B56A, B56alpha, B 56 alpha REGULATORY subunit of PP2A, B 56 alpha REGULATORY subunit of protein PHOSPHATASE 2A, B56 α, B 56 α REGULATORY subunit of PP2A, B 56 α REGULATORY subunit of protein PHOSPHATASE 2A, LOC100046393, PP2A B56 alpha, PP2A B56 α, PP2A B' alpha, PP2A B' α, Ppp2r5a predicted, PR61A, PR61alpha, protein phosphatase 2 regulatory subunit B'alpha, protein phosphatase 2, regulatory subunit B', alpha, protein phosphatase 2 regulatory subunit B'α, protein phosphatase 2, regulatory subunit B', α |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ppp2r5a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase binding
- protein phosphatase
- kinase inhibitor activity
- phosphatase
- protein phosphatase regulator
- Protein phosphatase 2A regulatory B subunit (B56 family)
- phosphatase activator
- protein binding
Pathways
Biological processes and signaling networks where the Ppp2r5a gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- AMPK Signaling
- ATM Signaling
- Autophagy
- Cardiac β-adrenergic Signaling
- CDK5 Signaling
- Cell Cycle Regulation by BTG Family Proteins
- Ceramide Signaling
- Cyclins and Cell Cycle Regulation
- Dopamine Receptor Signaling
- Dopamine-DARPP32 Feedback in cAMP Signaling
- ERK/MAPK Signaling
- HIPPO signaling
- ILK Signaling
- Mitotic Roles of Polo-Like Kinase
- mTOR Signaling
- Production of Nitric Oxide and Reactive Oxygen Species in Macrophages
- Regulation of eIF4 and p70S6K Signaling
- Role of CHK Proteins in Cell Cycle Checkpoint Control
- Role of Tissue Factor in Cancer
- Telomerase Signaling
- Tight Junction Signaling
- WNT/β-catenin Signaling
- Xenobiotic Metabolism Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- heart failure
- ischemic cardiomyopathy
- idiopathic perifoveal telangiectasia
- neoplastic cell transformation
- diffuse large B-cell lymphoma
- B-cell non-Hodgkin disease
- mature B-cell neoplasia
- cleft lip
- prostate cancer
- dilated cardiomyopathy
role in cell
- differentiation
- activation in
- cell death
- survival
- cell viability
- phosphorylation in
- expression in
- damage
- lipolysis in
- damage in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- Plasma Membrane
- centrosome
- sarcomere
- cytosol
- nuclear foci
- Z line
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ppp2r5a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- protein dephosphorylation
- positive regulation of protein dephosphorylation
- negative regulation of lipid kinase activity
Cellular Component
Where in the cell the gene product is active
- nucleus
- Z disc
- centrosome
- cytoplasm
- cytosol
- M band
- protein phosphatase type 2A complex
- chromosome, centromeric region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- phosphoprotein phosphatase activity
- protein binding
- protein phosphatase activator activity
- kinase binding
- protein phosphatase regulator activity