Chrna1 Gene Summary [Mouse]
This gene encodes an alpha subunit of the muscle-derived nicotinic acetylcholine receptor, a pentameric neurotransmitter receptor and member of the ligand-gated ion channel superfamily. The alpha subunit plays a role in substrate binding and channel gating. [provided by RefSeq, Nov 2012]
Details
| Type | Protein Coding |
| Official Symbol | Chrna1 |
| Official Name | cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle) [Source:MGI Symbol;Acc:MGI:87885] |
| Ensembl ID | ENSMUSG00000027107 |
| Bio databases IDs | |
| Aliases | cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle) |
| Synonyms | Acchor alpha, Acchor alpha-subunit, Acchor α, Acchor α-subunit, Achr-1, ACHRA, ACHRD, Acra, AI608266, CHOLINERGIC receptor, cholinergic receptor nicotinic alpha 1 subunit, cholinergic receptor nicotinic α 1 subunit, CHRNA, CMS1A, CMS1B, CMS2A, FCCMS, nAChR α 1, Nicotinic acetylcholine receptor, nicotinic acetylcholine receptor alpha1, Nicotinic acetylcholine receptor α subunit 1, SCCMS |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Chrna1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- excitatory extracellular ligand-gated ion channel
- channel/pore class transporter
- extracellular ligand-gated ion channel
- Cation transporter family protein
- protein binding
- pore domain
- ion channel
- acetylcholine receptor
- neurotransmitter receptor
- LGIC_ECD
- Neurotransmitter-gated ion-channel transmembrane region
- cytoplasmic domain
- Neurotransmitter-gated ion-channel ligand binding domain
- ligand-gated ion channel
- acetylcholine binding
- transmembrane receptor
- agonist binding domain
- cation channel
Pathways
Biological processes and signaling networks where the Chrna1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chronic obstructive pulmonary disease
- asthma
- pain
- postoperative pain
- morbid obesity
- postoperative nausea and vomiting
- respiratory insufficiency
- cancer
- nausea
- schizophrenia
role in cell
- expression in
- activation in
- proliferation
- apoptosis
- quantity
- binding in
- transmembrane potential
- development
- morphology
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
- synaptic membrane
- neuromuscular junctions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Chrna1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- synaptic transmission, cholinergic
- regulation of excitatory postsynaptic membrane potential
- muscle cell homeostasis
- neuromuscular synaptic transmission
- ion transmembrane transport
- neuromuscular process
- response to nicotine
- neuromuscular junction development
- neuron homeostasis
- musculoskeletal movement
- cation transport
- regulation of membrane potential
- skeletal muscle contraction
- skeletal muscle tissue growth
- membrane depolarization
- regulation of action potential in neuron
Cellular Component
Where in the cell the gene product is active
- postsynaptic membrane
- neuromuscular junction
- acetylcholine-gated channel complex
- synapse
- neuron projection
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- acetylcholine receptor activity
- acetylcholine-gated cation channel activity
- acetylcholine binding