Mthfs Gene Summary [Mouse]
Predicted to enable 5-formyltetrahydrofolate cyclo-ligase activity; double-stranded DNA binding activity; and heterocyclic compound binding activity. Predicted to be involved in folic acid-containing compound biosynthetic process and tetrahydrofolate interconversion. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to several human genes including MTHFS (methenyltetrahydrofolate synthetase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Mthfs |
| Official Name | 5, 10-methenyltetrahydrofolate synthetase [Source:MGI Symbol;Acc:MGI:1340032] |
| Ensembl ID | ENSMUSG00000066442 |
| Bio databases IDs | |
| Aliases | 5, 10-methenyltetrahydrofolate synthetase |
| Synonyms | 1110034I12Rik, 2310020H23Rik, 5, 10-methenyltetrahydrofolate synthetase, HsT19268, methenyltetrahydrofolate synthetase, NEDMEHM |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mthfs often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- folic acid binding
- 5-formyltetrahydrofolate cyclo-ligase family
- double-stranded DNA binding
- ATP binding
- enzyme
- protein binding
- 5-formyltetrahydrofolate cyclo-ligase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- cytosol
- mitochondrial matrix
- mitochondrial nucleoids
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mthfs gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glutamate metabolic process
- folic acid-containing compound biosynthetic process
- folic acid metabolic process
- tetrahydrofolate interconversion
- tetrahydrofolate metabolic process
- formate metabolic process
- folic acid catabolic process
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
- cytoplasm
- mitochondrion
- cytosol
Molecular Function
What the gene product does at the molecular level
- ATP binding
- metal ion binding
- 5-formyltetrahydrofolate cyclo-ligase activity
- folic acid binding