Lyar Gene Summary [Mouse]
Predicted to enable several functions, including DNA-binding transcription factor binding activity; identical protein binding activity; and transcription regulator inhibitor activity. Involved in negative regulation of transcription by RNA polymerase II and positive regulation of phagocytosis. Located in nucleolus and photoreceptor outer segment. Is expressed in several structures, including gonad; hemolymphoid system; jaw; liver; and metanephros. Orthologous to human LYAR (Ly1 antibody reactive). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lyar |
| Official Name | Ly1 antibody reactive clone [Source:MGI Symbol;Acc:MGI:107470] |
| Ensembl ID | ENSMUSG00000067367 |
| Bio databases IDs | |
| Aliases | Ly1 antibody reactive clone |
| Synonyms | Ly1 antibody reactive, Ly1 antibody reactive clone, MLZ-264, ZC2HC2, ZLYAR |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lyar often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Acetyl-coA carboxylase zinc finger domain
- LYAR-type C2HC zinc finger
- transcription factor binding
- protein binding
- identical protein binding
- DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colon cancer
- age-related macular degeneration
regulates
- DNA endogenous promoter
- DNA promoter
- Fetal hemoglobin
- RNA polymerase II
role in cell
- production in
- killing
- phagocytosis by
- development
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Nucleus
- nucleoplasm
- nucleoli
- photoreceptor outer segments
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lyar gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- innate immune response
- erythrocyte development
- rRNA processing
- positive regulation of phagocytosis
- negative regulation of innate immune response
- positive regulation of transcription from RNA polymerase I promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- nucleolus
- photoreceptor outer segment
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- identical protein binding
- RNA binding
- protein binding
- metal ion binding