S1pr3 Gene Summary [Mouse]
This gene encodes a member of the G-protein coupled receptor 1 family. The encoded protein is a receptor for the lysophospholipid sphingosine 1-phosphate. The gene product functions in endothelial cells and is involved in vascular and heart development. The gene product mediates HDL and HDL-associated lysophospholipid-induced vasorelaxation, and it coordinates with other lysophospholipid receptors in the process of angiogenesis. [provided by RefSeq, Jan 2010]
Details
| Type | Protein Coding |
| Official Symbol | S1pr3 |
| Official Name | sphingosine-1-phosphate receptor 3 [Source:MGI Symbol;Acc:MGI:1339365] |
| Ensembl ID | ENSMUSG00000067586 |
| Bio databases IDs | |
| Aliases | sphingosine-1-phosphate receptor 3 |
| Synonyms | bA791O21.3, C9orf108, C9orf47, EDG-3, Edg3l, LPB3, S1P3, sphingosine-1-phosphate receptor 3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse S1pr3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- intracellular loop
- Cholecystokinin A receptor, N-terminal
- lipid binding
- integrin binding
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the S1pr3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- neoplasia
- lung squamous cell carcinoma
- squamous cell lung cancer
- edema
- abdominal aortic aneurysm
- torticollis
- angioimmunoblastic T-cell lymphoma
- T-cell non-Hodgkin disease
- mature T-cell neoplasia
role in cell
- expression in
- phosphorylation in
- degeneration
- activation in
- cell viability
- apoptosis
- production in
- accumulation in
- differentiation
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- presynaptic regions
- cell surface
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse S1pr3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
- inflammatory response
- Notch signaling pathway
- G-protein coupled receptor signaling pathway
- positive regulation of cell proliferation
- regulation of metabolic process
- anatomical structure morphogenesis
- regulation of interleukin-1 beta production
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
- sphingosine-1-phosphate signaling pathway
- elevation of cytosolic calcium ion concentration
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- sphingosine-1-phosphate receptor activity
- G-protein coupled receptor activity
- protein binding
- integrin binding
- lipid binding