Tnfrsf13c Gene Summary [Mouse]
Predicted to enable signaling receptor activity. Acts upstream of or within several processes, including positive regulation of germinal center formation; positive regulation of lymphocyte activation; and positive regulation of type II interferon production. Located in external side of plasma membrane. Is expressed in genitourinary system; hemolymphoid system gland; lung; and retina. Human ortholog(s) of this gene implicated in common variable immunodeficiency 4. Orthologous to human TNFRSF13C (TNF receptor superfamily member 13C). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tnfrsf13c |
| Official Name | tumor necrosis factor receptor superfamily, member 13c [Source:MGI Symbol;Acc:MGI:1919299] |
| Ensembl ID | ENSMUSG00000068105 |
| Bio databases IDs | |
| Aliases | tumor necrosis factor receptor superfamily, member 13c |
| Synonyms | 2010006P15Rik, BAFF-R, BCMD, Bcmd-1, BR3, BROMIX, CD268, CVID4, Lvis22, prolixin, RGD1560810, TNF receptor superfamily member 13C, tumor necrosis factor receptor superfamily, member 13c, tumour necrosis factor receptor superfamily, member 13c |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tnfrsf13c often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- cytoplasmic domain
- BAFF-R, TALL-1 binding
- transmembrane receptor
Pathways
Biological processes and signaling networks where the Tnfrsf13c gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- proteinuria
- systemic lupus erythematosus
- Sjögren syndrome
- common variable immunodeficiency type 4
- mantle cell lymphoma
- plasma cell myeloma
- chronic autoimmune hepatitis
- lupus nephritis
- primary immune thrombocytopenia
role in cell
- signaling in
- expression in
- proliferation
- function
- phosphorylation in
- activation in
- cell viability
- accumulation in
- activation
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- cellular membrane
- Nucleus
- plasma membrane extracellular face
- nucleoplasm
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tnfrsf13c gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- tumor necrosis factor-mediated signaling pathway
- T cell costimulation
- B cell costimulation
- positive regulation of B cell proliferation
- adaptive immune response
- positive regulation of T cell proliferation
Cellular Component
Where in the cell the gene product is active
- external side of plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- signaling receptor activity