Sppl2a Gene Summary [Mouse]
Predicted to enable aspartic endopeptidase activity, intramembrane cleaving and protein homodimerization activity. Involved in membrane protein proteolysis and regulation of immune response. Located in late endosome membrane and lysosomal membrane. Is expressed in genitourinary system; skeleton; and thymus primordium. Human ortholog(s) of this gene implicated in immunodeficiency 86. Orthologous to human SPPL2A (signal peptide peptidase like 2A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sppl2a |
| Official Name | signal peptide peptidase like 2A [Source:MGI Symbol;Acc:MGI:1913802] |
| Ensembl ID | ENSMUSG00000027366 |
| Bio databases IDs | |
| Aliases | signal peptide peptidase like 2A |
| Synonyms | 2010106G01Rik, AK080421, C130089K23Rik, IMD86, IMP3, PSL2, RGD1563001, signal peptide peptidase-like 2A |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sppl2a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- aspartic endopeptidase, intramembrane cleaving
- PA domain
- PA
- peptidase
- protein homodimerization
- protein binding
- Signal peptide peptidase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- immunodeficiency
- ischemic stroke
- Alzheimer disease
- venous thromboembolism
- preeclampsia
- refractive error
- acne
- coronary artery disease
- vertigo
- immunodeficiency 86
role in cell
- expression in
- quantity
- differentiation
- formation in
- accumulation
- function
- number
- loss
- processing in
- accumulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- intracellular membrane-bounded organelle
- cellular membrane
- Golgi membrane
- lysosome membrane
- endosomal membrane
- late endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sppl2a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- membrane protein ectodomain proteolysis
- membrane protein intracellular domain proteolysis
- membrane protein proteolysis
- regulation of tumor necrosis factor-mediated signaling pathway
- regulation of immune response
Cellular Component
Where in the cell the gene product is active
- late endosome membrane
- extracellular vesicular exosome
- intracellular membrane-bounded organelle
- membrane
- Golgi-associated vesicle membrane
- late endosome
- lysosomal membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein homodimerization activity
- protein binding
- aspartic endopeptidase activity, intramembrane cleaving