Dok1 Gene Summary [Mouse]
Acts upstream of or within Ras protein signal transduction; cell surface receptor protein tyrosine kinase signaling pathway; and macrophage colony-stimulating factor signaling pathway. Predicted to be located in cytosol and nucleus. Predicted to be active in cytoplasm. Is expressed in central nervous system and retina. Orthologous to human DOK1 (docking protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dok1 |
| Official Name | docking protein 1 [Source:MGI Symbol;Acc:MGI:893587] |
| Ensembl ID | ENSMUSG00000068335 |
| Bio databases IDs | |
| Aliases | docking protein 1 |
| Synonyms | docking protein 1, P62DOK, pp62 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dok1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- PTB domain (IRS-1 type)
- Rasgap binding domain
- Dok homology domain
- PH domain
- protein binding
- phosphotyrosine binding domain
- Pleckstrin homology-like domain
- cytosolic tail domain
- tyrosine phosphorylation site
- GTPase activating protein binding domain
Pathways
Biological processes and signaling networks where the Dok1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- epithelial neoplasia
- Waldenström macroglobulinemia
- androgenic alopecia
- runting
- leukemia
- uterine leiomyoma
- leiomyomatosis
- lung adenocarcinoma formation
- non-squamous non-small cell lung cancer
role in cell
- growth
- expression in
- colony formation
- migration
- proliferation
- signaling in
- function
- quantity
- size
- development
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cytoskeleton
- Cytoplasm
- intracellular space
- membrane skeleton
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dok1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- macrophage colony-stimulating factor signaling pathway
- transmembrane receptor protein tyrosine kinase signaling pathway
- cell surface receptor signaling pathway
- Ras protein signal transduction
- positive regulation of MAPK cascade
Cellular Component
Where in the cell the gene product is active
- nucleus
- perinuclear region of cytoplasm
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding