Irgm2 Gene Summary [Mouse]
Enables GTPase activity. Involved in several processes, including defense response to protozoan; negative regulation of non-canonical inflammasome complex assembly; and protein targeting to vacuolar membrane. Acts upstream of or within response to bacterium. Is active in Golgi membrane; cytosol; and vacuolar membrane. Human ortholog(s) of this gene implicated in inflammatory bowel disease 19 and tuberculosis. Orthologous to human IRGM (immunity related GTPase M). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Irgm2 |
| Official Name | immunity-related GTPase family M member 2 [Source:MGI Symbol;Acc:MGI:1926262] |
| Ensembl ID | ENSMUSG00000069874 |
| Bio databases IDs | |
| Aliases | immunity-related GTPase family M member 2 |
| Synonyms | GTPI, Ifggd2, Iigp2, immunity-related GTPase family M member 2, Interferon-gamma-induced GTPase, Interferon-γ-induced GTPase |
| Species | Mouse, Mus musculus |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Irgm2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CARD domain binding
- protein kinase activator
- phospholipid binding
- binding protein
- protein kinase binding
- small monomeric GTPase
- protein binding activity, bridging
- Interferon-inducible GTPase (IIGP)
- GTPase
- protein domain specific binding
- enzyme
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- parasitophorous vacuole
- vacuole
- Golgi Apparatus
- Mitochondria
- cytosol
- Golgi membrane
- autophagic vacuoles