Apcdd1 Gene Summary [Mouse]
Predicted to enable Wnt-protein binding activity and identical protein binding activity. Involved in regulation of odontogenesis of dentin-containing tooth. Acts upstream of or within astrocyte cell migration. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; brain; branchial arch; ear; and reproductive system. Human ortholog(s) of this gene implicated in hypotrichosis 1. Orthologous to human APCDD1 (APC down-regulated 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Apcdd1 |
| Official Name | adenomatosis polyposis coli down-regulated 1 [Source:MGI Symbol;Acc:MGI:3513977] |
| Ensembl ID | ENSMUSG00000071847 |
| Bio databases IDs | |
| Aliases | adenomatosis polyposis coli down-regulated 1 |
| Synonyms | AB023957, adenomatosis polyposis coli down-regulated 1, APC down-regulated 1, AU041258, B7323, DRAPC1, EIG180, FP7019, HHS, HTS, HYPT1, LOC682861 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Apcdd1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Wnt-protein binding
- Adenomatosis polyposis coli down-regulated 1
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetic nephropathy
- gout
- peritoneal endometriosis
- ulcerative colitis
- alopecia
- hypotrichosis type 1
regulates
- WNT
role in cell
- growth
- migration by
- development
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Apcdd1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- astrocyte cell migration
- hair follicle development
- Wnt receptor signaling pathway
- negative regulation of Wnt receptor signaling pathway
- regulation of odontogenesis of dentin-containing tooth
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- Wnt-protein binding