APCDD1 Gene Summary [Human]
This locus encodes an inhibitor of the Wnt signaling pathway. Mutations at this locus have been associated with hereditary hypotrichosis simplex. Increased expression of this gene may also be associated with colorectal carcinogenesis.[provided by RefSeq, Sep 2010]
Details
| Type | Protein Coding |
| Official Symbol | APCDD1 |
| Official Name | APC down-regulated 1 [Source:HGNC Symbol;Acc:HGNC:15718] |
| Ensembl ID | ENSG00000154856 |
| Bio databases IDs | |
| Aliases | APC down-regulated 1 |
| Synonyms | AB023957, adenomatosis polyposis coli down-regulated 1, APC down-regulated 1, AU041258, B7323, DRAPC1, EIG180, FP7019, HHS, HTS, HYPT1, LOC682861 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human APCDD1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Wnt-protein binding
- Adenomatosis polyposis coli down-regulated 1
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human APCDD1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- astrocyte cell migration
- hair follicle development
- Wnt receptor signaling pathway
- negative regulation of Wnt receptor signaling pathway
- regulation of odontogenesis of dentin-containing tooth
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- Wnt-protein binding