Ripply1 Gene Summary [Mouse]
Acts upstream of or within several processes, including Notch signaling pathway; bone morphogenesis; and somite rostral/caudal axis specification. Predicted to be active in nucleus. Is expressed in somite; tail unsegmented mesenchyme; tongue; and trunk unsegmented mesenchyme. Orthologous to human RIPPLY1 (ripply transcriptional repressor 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ripply1 |
| Official Name | ripply transcriptional repressor 1 [Source:MGI Symbol;Acc:MGI:3614797] |
| Ensembl ID | ENSMUSG00000072945 |
| Bio databases IDs | |
| Aliases | ripply transcriptional repressor 1 |
| Synonyms | ripply transcriptional repressor 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ripply1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- protein binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ripply1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of transcription, DNA-dependent
- somite specification
- embryonic pattern specification
- somite rostral/caudal axis specification
Cellular Component
Where in the cell the gene product is active
- nucleus
Molecular Function
What the gene product does at the molecular level
- protein binding