ARHGDIG
ARHGDIG Gene Summary
The GDP-dissociation inhibitors (GDIs) play a primary role in modulating the activation of GTPases by inhibiting the exchange of GDP for GTP. See ARHGDIB (MIM 602843).[supplied by OMIM, Nov 2010]
Details
| Type | Protein Coding |
| Official Symbol | ARHGDIG |
| Official Name | Rho GDP dissociation inhibitor gamma [Source:HGNC Symbol;Acc:HGNC:680] |
| Ensembl ID | ENSG00000242173 |
| Bio databases IDs | |
| Aliases | Rho GDP dissociation inhibitor gamma, RhoGDI gamma |
| Synonyms | Gdi5,Rho-GDI2,RHOGDI-3,RHOGDI gamma,RHOGDI γ,Rho GDP dissociation inhibitor gamma,Rho GDP dissociation inhibitor γ,RIP2 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GTPase regulator
- GDP-dissociation inhibitor
- Rho GDP-dissociation inhibitor
- protein binding
- RHO protein GDP dissociation inhibitor
Pathways
Biological processes and signaling networks where the ARHGDIG gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- VDAC1
- AGTR1
- CDC42
- RHOG
- RAC1
- KXD1
- RHOB
- RHOH
- GDP
- RAS homolog
disease
- metastasis
- diabetic nephropathy
regulated by
- tetradecanoylphorbol acetate
- HNF4A
- PRKCA
- PPARA
- ADCYAP1
- PGR
- PSEN1
- PSEN2
regulates
- CDC42
- RAC1
- LPAR1
- PADI3
- OXLD1
- RGS2
- MARCKS
- PADI1
- COL5A2
- EDN1
role in cell
- adhesion
- cell rounding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Plasma Membrane
- cytosol
- cytoplasmic vesicles
- Golgi cisternae
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the ARHGDIG gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- regulation of protein localization
- negative regulation of cell adhesion
- blastocyst hatching
- Rho protein signal transduction
CELLULAR COMPONENT
Where in the cell the gene product is active
- membrane
- cytoplasmic vesicle
- cytosol
- plasma membrane
MOLECULAR FUNCTION
What the gene product does at the molecular level
- protein binding
- Rho GDP-dissociation inhibitor activity
- GTPase activator activity