Fancm Gene Summary [Mouse]
Predicted to enable DNA helicase activity; chromatin binding activity; and four-way junction DNA binding activity. Predicted to be involved in DNA metabolic process and positive regulation of protein monoubiquitination. Predicted to be located in chromatin and nucleoplasm. Predicted to be part of FANCM-MHF complex and Fanconi anaemia nuclear complex. Is expressed in lung; mandible; and temporal bone petrous part. Human ortholog(s) of this gene implicated in primary ovarian insufficiency 15 and spermatogenic failure 28. Orthologous to human FANCM (FA complementation group M). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Fancm |
| Official Name | Fanconi anemia, complementation group M [Source:MGI Symbol;Acc:MGI:2442306] |
| Ensembl ID | ENSMUSG00000055884 |
| Bio databases IDs | |
| Aliases | Fanconi anemia, complementation group M |
| Synonyms | AI427100, C730036B14Rik, D12Ertd364e, FAAP250, FA complementation group M, Fanconi anaemia, complementation group M, Fanconi anemia, complementation group M, KIAA1596, POF15, RGD1307897, SPGF28 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fancm often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ERCC4 domain
- FANCM to MHF binding domain
- DEAD/DEAH box helicase
- helicase superfamily c-terminal domain
- chromatin binding
- enzyme
- protein binding
- PDDEXK family nucleases
- Helicase conserved C-terminal domain
- nuclease domain of XPF/MUS81 family proteins
- Type III restriction enzyme, res subunit
- N-terminal helicase domain of the DEAD-box helicase superfamily
- helicase_insert_domain
- DEAD-like helicases superfamily
- P-loop containing Nucleoside Triphosphate Hydrolases
Pathways
Biological processes and signaling networks where the Fancm gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- hyperplasia
- cancer
- metastasis
- Fanconi anemia
- spermatogenic failure 28
- abdominal cancer
- Fanconi anemia, group A
- premature ovarian failure type 15
- hereditary cancer-predisposing syndrome
role in cell
- cell death
- formation
- formation in
- replication in
- recruitment in
- quantity
- cell viability
- processing
- association
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fancm gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA duplex unwinding
- resolution of meiotic recombination intermediates
- replication fork processing
- double-strand break repair via synthesis-dependent strand annealing
Cellular Component
Where in the cell the gene product is active
- Fanconi anaemia nuclear complex
- cytosol
- FANCM-MHF complex
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- protein binding
- RNA helicase activity
- nuclease activity
- four-way junction helicase activity
- chromatin binding
- 3'-5' DNA helicase activity
- four-way junction DNA binding