Rad21l Gene Summary [Mouse]
Predicted to enable chromatin binding activity. Acts upstream of or within several processes, including double-strand break repair via homologous recombination; homologous chromosome segregation; and seminiferous tubule development. Located in lateral element. Part of meiotic cohesin complex. Is expressed in brain; gonad; and metanephros. Orthologous to human RAD21L1 (RAD21 cohesin complex component like 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rad21l |
| Official Name | RAD21-like (S. pombe) [Source:MGI Symbol;Acc:MGI:3652039] |
| Ensembl ID | ENSMUSG00000074704 |
| Bio databases IDs | |
| Aliases | RAD21-like (S. pombe) |
| Synonyms | dJ545L17.2, Gm14160, LOC682264, MeiRAD21L, RAD21 cohesin complex component like 1, RAD21L, RAD21-like (S. pombe) |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rad21l often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Middle HEAT-repeat binding domain of Rad21/Rec8-like proteins
- N terminus of Rad21 / Rec8 like protein
- Conserved region of Rad21 / Rec8 like protein
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromosome
- synaptonemal complexes
- chromosomal arms
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rad21l gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sister chromatid cohesion
- meiotic cell cycle
- chromosome segregation
Cellular Component
Where in the cell the gene product is active
- nucleus
- meiotic cohesin complex
- chromosome
Molecular Function
What the gene product does at the molecular level
- chromatin binding