Stag3 Gene Summary [Mouse]
Predicted to enable chromatin binding activity. Acts upstream of or within homologous chromosome pairing at meiosis and protein localization to chromosome. Located in lateral element; male germ cell nucleus; and transverse filament. Part of meiotic cohesin complex. Is expressed in bone marrow; brain; and genitourinary system. Human ortholog(s) of this gene implicated in primary ovarian insufficiency 8 and spermatogenic failure 61. Orthologous to human STAG3 (STAG3 cohesin complex component). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Stag3 |
| Official Name | stromal antigen 3 [Source:MGI Symbol;Acc:MGI:1355311] |
| Ensembl ID | ENSMUSG00000036928 |
| Bio databases IDs | |
| Aliases | stromal antigen 3 |
| Synonyms | LOC102553065, SA-2, SA3, SPGF61, STAG3 cohesin complex component |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Stag3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- STAG domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- premature ovarian failure type 8
- premature ovarian failure
- colorectal cancer
- spermatogenic failure 61
- androgenic alopecia
- organismal death
- Alzheimer disease
- alcoholism
- major depression
role in cell
- proliferation
- migration
- apoptosis
- quantity
- mitosis
- invasion by
- expression in
- formation
- G1/S phase transition
- synapsis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytoplasmic aggregates
- chromosome
- interchromatin space
- nucleoplasm
- nucleoli
- kinetochores
- centromeres
- synaptonemal complexes
- chromosomal arms
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Stag3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sister chromatid cohesion
- establishment of meiotic sister chromatid cohesion
- synaptonemal complex assembly
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular space
- meiotic cohesin complex
- nucleolus
- chromosome, centromeric region
- chromatin
- synaptonemal complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- chromatin binding