Pik3c3

Enables protein kinase activity. Involved in cellular response to glucose starvation; macroautophagy; and synaptic vesicle endocytosis. Acts upstream of or within several processes, including phosphatidylinositol-3-phosphate biosynthetic process; protein localization to phagophore assembly site; and protein phosphorylation. Located in phagocytic vesicle. Part of phosphatidylinositol 3-kinase complex, class III. Is active in GABA-ergic synapse; endosome; and glutamatergic synapse. Is expressed in several structures, including Meckel's cartilage; cardiovascular system; limb; and skeleton. Orthologous to human PIK3C3 (phosphatidylinositol 3-kinase catalytic subunit type 3). [provided by Alliance of Genome Resources, Apr 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pik3c3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Pik3c3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the mouse Pik3c3 gene, providing context for its role in the cell.