Kdelr2 Gene Summary [Mouse]
Predicted to enable KDEL sequence binding activity. Predicted to be involved in protein retention in ER lumen and retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Predicted to be located in Golgi membrane and endoplasmic reticulum membrane. Predicted to be active in cis-Golgi network and endoplasmic reticulum. Predicted to colocalize with COPI-coated vesicle membrane. Is expressed in limb; otic capsule; palatal shelf; and skeleton. Human ortholog(s) of this gene implicated in osteogenesis imperfecta type 21. Orthologous to human KDELR2 (KDEL endoplasmic reticulum protein retention receptor 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Kdelr2 |
| Official Name | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 [Source:MGI Symbol;Acc:MGI:1914163] |
| Ensembl ID | ENSMUSG00000079111 |
| Bio databases IDs | |
| Aliases | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 |
| Synonyms | 1110007A14Rik, ELP-1, ERD2.2, KDEL endoplasmic reticulum protein retention receptor 2, KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2, LOC100360920, OI21 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Kdelr2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- KDEL sequence binding
- ER lumen protein retaining receptor
Pathways
Biological processes and signaling networks where the Kdelr2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- osteogenesis imperfecta type XXI
- metastasis
- autosomal dominant Emery-Dreifuss muscular dystrophy
- epidermal hyperplasia
- attention deficit hyperactivity disorder
- coronary artery disease
- Duchenne muscular dystrophy
- irritable bowel syndrome
- juvenile dermatomyositis
- psoriasis
role in cell
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell surface
- Golgi region
- cellular membrane
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- Golgi membrane
- cis Golgi networks
- transport vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Kdelr2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ER to Golgi vesicle-mediated transport
- retrograde vesicle-mediated transport, Golgi to ER
- protein transport
- maintenance of protein localization in endoplasmic reticulum
- protein retention in ER lumen
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- cis-Golgi network
- membrane
- Golgi membrane
- endoplasmic reticulum
- transport vesicle
- COPI coated vesicle membrane
Molecular Function
What the gene product does at the molecular level
- KDEL sequence binding
- ER retention sequence binding