Gnb3 Gene Summary [Mouse]
Predicted to enable GTPase binding activity; signaling receptor complex adaptor activity; and spectrin binding activity. Predicted to be involved in several processes, including cell volume homeostasis; regulation of fat cell differentiation; and regulation of lipid metabolic process. Located in dendrite. Part of heterotrimeric G-protein complex. Is expressed in several structures, including brain; eye; ganglia; gut; and spleen. Human ortholog(s) of this gene implicated in artery disease (multiple); congenital stationary night blindness 1H; depressive disorder; familial hyperlipidemia; and type 2 diabetes mellitus. Orthologous to human GNB3 (G protein subunit beta 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gnb3 |
| Official Name | guanine nucleotide binding protein (G protein), beta 3 [Source:MGI Symbol;Acc:MGI:95785] |
| Ensembl ID | ENSMUSG00000023439 |
| Bio databases IDs | |
| Aliases | guanine nucleotide binding protein (G protein), beta 3 |
| Synonyms | CSNB1H, Gbeta3, G protein subunit beta 3, G protein subunit β 3, G protein β 3, guanine nucleotide binding protein (G protein), beta 3, guanine nucleotide binding protein (G protein), β 3, Gβ3, HG2D |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gnb3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- WD40 repeats
- WD domain, G-beta repeat
- spectrin binding
- enzyme binding
- GTPase
- WD40
- protein binding
Pathways
Biological processes and signaling networks where the Gnb3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- AMPK Signaling
- Antiproliferative Role of Somatostatin Receptor 2
- Apelin Endothelial Signaling Pathway
- Apelin Muscle Signaling Pathway
- CCR3 Signaling in Eosinophils
- CCR5 Signaling in Macrophages
- CXCR4 Signaling
- Endocannabinoid Developing Neuron Pathway
- Ephrin B Signaling
- fMLP Signaling in Neutrophils
- G Beta Gamma Signaling
- Glutamate Receptor Signaling
- Gustation Pathway
- Gαq Signaling
- Gαs Signaling
- IL-1 Signaling
- Molecular Mechanisms of Cancer
- P2Y Purinergic Receptor Signaling Pathway
- Phospholipase C Signaling
- Phototransduction Pathway
- Protein Kinase A Signaling
- RhoGDI Signaling
- Thrombin Signaling
- α-Adrenergic Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- diabetes mellitus
- chronic kidney disease
- weight loss
- weight gain
- obesity
- congenital stationary night blindness type 1h
- insulin resistance
- hypertension
- thyroid gland neoplasm
role in cell
- quantity
- expression in
- differentiation
- photopic b-wave response
- lipolysis in
- scotopic b-wave response
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cytosol
- perikaryon
- dendrites
- cone outer segments
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gnb3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of locomotion involved in locomotory behavior
- regulation of glucose metabolic process
- G-protein coupled receptor signaling pathway
- regulation of hormone metabolic process
- regulation of gene expression
- regulation of fat cell differentiation
- regulation of blood pressure
- cell volume homeostasis
- regulation of triglyceride metabolic process
- regulation of feeding behavior
- regulation of cholesterol metabolic process
Cellular Component
Where in the cell the gene product is active
- dendrite
- heterotrimeric G-protein complex
- extracellular vesicular exosome
- cytoplasm
- cell body
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- spectrin binding
- GTPase activity
- GTPase binding
- receptor signaling complex scaffold activity