Cfb Gene Summary [Mouse]
Predicted to enable serine-type endopeptidase activity. Acts upstream of or within complement activation, alternative pathway. Predicted to be located in extracellular region. Is expressed in embryo and liver lobe. Human ortholog(s) of this gene implicated in several diseases, including atypical hemolytic-uremic syndrome; autoimmune disease (multiple); eye disease (multiple); glomerulonephritis (multiple); and sickle cell anemia. Orthologous to human CFB (complement factor B). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cfb |
| Official Name | complement factor B [Source:MGI Symbol;Acc:MGI:105975] |
| Ensembl ID | ENSMUSG00000090231 |
| Bio databases IDs | |
| Aliases | complement factor B |
| Synonyms | AHUS4, AI255840, ARMD14, BF, BFD, C2, CFAB, CFBD, Complement Factor B, Da1-24, Factor B, FB, FBI12, GBG, H2-Bf, PBF2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cfb often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Trypsin-like serine protease
- Tryp_SPc
- von Willebrand factor (vWF) type A domain
- peptidase
- von Willebrand factor type A domain
- protein binding
- CCP
- trypsin
- serine endopeptidase
- alternative-complement-pathway C3/C5 convertase
- vWFA
- Sushi repeat (SCR repeat)
- SUSHI repeat
Pathways
Biological processes and signaling networks where the Cfb gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- renal failure
- kidney disease
- kidney injury
- COVID-19
- Alzheimer disease
- complement factor B deficiency
- major depression
- prostatic intraepithelial neoplasm
- prostatic intraepithelial neoplasia
- blistering
role in cell
- apoptosis
- expression in
- cellular infiltration by
- proliferation
- activation in
- synthesis in
- complement-mediated lysis
- phagocytosis by
- hyperproduction in
- mitochondrial respiration in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- Nucleus
- Plasma Membrane
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cfb gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- complement activation
- complement activation, alternative pathway
- response to bacterium
- proteolysis
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- blood microparticle
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- serine-type endopeptidase activity
- complement binding