Lamtor3 Gene Summary [Mouse]
Enables kinase activator activity. Acts upstream of or within positive regulation of MAPK cascade and protein localization to cell junction. Located in late endosome. Is expressed in several structures, including central nervous system; genitourinary system; and retina. Orthologous to human LAMTOR3 (late endosomal/lysosomal adaptor, MAPK and MTOR activator 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lamtor3 |
| Official Name | late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 [Source:MGI Symbol;Acc:MGI:1929467] |
| Ensembl ID | ENSMUSG00000091512 |
| Bio databases IDs | |
| Aliases | late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 |
| Synonyms | late endosomal/lysosomal adaptor, MAPK and MTOR activator 3, LOC100132990, MAP2K1IP1, MAPBP, MAPKSP1, Mek binding partner 1, MP1, PRO0633, Ragulator3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lamtor3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Mitogen-activated protein kinase kinase 1 interacting
- guanyl-nucleotide exchange factor
- kinase activator
- protein binding
Pathways
Biological processes and signaling networks where the Lamtor3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neonatal late-onset sepsis
- hypertrophic scar
role in cell
- proliferation
- survival
- expression in
- differentiation
- self-renewal
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent resistant lipid raft fraction
- Plasma Membrane
- tertiary granule membrane
- specific granule membrane
- lysosome membrane
- endosomal membrane
- late endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lamtor3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to amino acid stimulus
- protein localization
- positive regulation of MAPK cascade
- positive regulation of TOR signaling cascade
Cellular Component
Where in the cell the gene product is active
- late endosome membrane
- extracellular vesicular exosome
- focal adhesion
- Ragulator complex
- endosome membrane
- tertiary granule membrane
- plasma membrane
- lysosomal membrane
- specific granule membrane
Molecular Function
What the gene product does at the molecular level
- kinase activator activity
- protein binding
- guanyl-nucleotide exchange factor activity
- binding, bridging