Uvrag Gene Summary [Mouse]
Enables SH3 domain binding activity and SNARE binding activity. Involved in DNA repair; chromosome segregation; and microtubule cytoskeleton organization. Acts upstream of or within SNARE complex assembly and symbiont entry into host cell. Located in phagocytic vesicle. Part of protein-containing complex. Is expressed in midgut; smooth muscle tissue; and thyroid gland. Orthologous to human UVRAG (UV radiation resistance associated). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Uvrag |
| Official Name | UV radiation resistance associated gene [Source:MGI Symbol;Acc:MGI:1925860] |
| Ensembl ID | ENSMUSG00000035354 |
| Bio databases IDs | |
| Aliases | UV radiation resistance associated gene |
| Synonyms | 9530039D02Rik, BB124205, DHTX, LOC100911792, p63, UV radiation resistance associated, UV radiation resistance associated gene, UVRAG1, UVRAGL, VPS38 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Uvrag often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SNARE binding
- Vacuolar protein sorting 38
- coiled-coil domain
- Vacuolar sorting 38 and autophagy-related subunit 14
- protein binding
- Protein kinase C conserved region 2 (CalB)
- SH3-domain binding
Pathways
Biological processes and signaling networks where the Uvrag gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- neoplasia
- stroke
- tumorigenesis
- Duchenne muscular dystrophy
- organismal death
- ischemic stroke
role in cell
- expression in
- growth
- proliferation
- formation
- migration
- quantity
- maturation
- fusion
- generation
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cellular membrane
- endosomes
- centrosome
- lysosome
- Endoplasmic Reticulum
- midbody
- autophagic vacuoles
- early endosomes
- late endosomes
- phagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Uvrag gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- viral entry into host cell
- DNA repair
- spindle organization
- centrosome cycle
- retrograde vesicle-mediated transport, Golgi to ER
- SNARE complex assembly
- phosphatidylinositol-3-phosphate biosynthetic process
- chromosome segregation
- maintenance of Golgi location
- receptor catabolic process
- autophagy
- regulation of autophagy
- regulation of cytokinesis
- multivesicular body sorting pathway
- regulation of protein serine/threonine kinase activity
Cellular Component
Where in the cell the gene product is active
- DNA-dependent protein kinase complex
- phosphatidylinositol 3-kinase complex, class III
- phagocytic vesicle
- late endosome
- endoplasmic reticulum
- chromosome, centromeric region
- lytic vacuole
- autophagic vacuole membrane
- lysosome
- centrosome
- early endosome
- endosome
- cytoplasm
- midbody
- endoplasmic reticulum-Golgi intermediate compartment membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- SNARE binding
- SH3 domain binding