Gbp5 Gene Summary [Mouse]
Predicted to enable several functions, including G protein activity; GTP binding activity; and protein homodimerization activity. Involved in several processes, including positive regulation of cytokine production; positive regulation of defense response; and response to bacterium. Acts upstream of or within several processes, including cellular response to type II interferon; disruption of plasma membrane integrity in another organism; and protein-containing complex assembly. Located in cytoplasmic vesicle. Is active in symbiont cell surface. Orthologous to human GBP5 (guanylate binding protein 5). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Gbp5 |
| Official Name | guanylate binding protein 5 [Source:MGI Symbol;Acc:MGI:2429943] |
| Ensembl ID | ENSMUSG00000105504 |
| Bio databases IDs | |
| Aliases | guanylate binding protein 5 |
| Synonyms | 5330409J06Rik, Gbp5a, guanylate binding protein 5, Ifn-induced guanylate-binding protein 5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gbp5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- endopeptidase inhibitor
- Vacuolar (H+)-ATPase G subunit
- GTPase regulator
- Guanylate-binding protein, N-terminal domain
- small monomeric GTPase
- protein homodimerization
- GTPase
- enzyme
- protein binding
- identical protein binding
- P-loop containing Nucleoside Triphosphate Hydrolases
- Guanylate-binding protein, C-terminal domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatitis
- osteopenia
- hepatic injury
- dextran sodium sulfate-induced colitis
role in cell
- response
- apoptosis
- response by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- Plasma Membrane
- Golgi Apparatus
- Golgi membrane
- cytoplasmic vesicles