Unc5c Gene Summary [Mouse]
Enables netrin receptor activity involved in chemorepulsion and tubulin binding activity. Involved in chemorepulsion of axon and netrin-activated signaling pathway. Acts upstream of or within several processes, including nervous system development; positive regulation of apoptotic process; and regulation of neuron migration. Located in several cellular components, including filopodium; growth cone; and lamellipodium. Is expressed in several structures, including brain; embryo mesenchyme; gonad; retina; and skeleton. Orthologous to human UNC5C (unc-5 netrin receptor C). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Unc5c |
| Official Name | unc-5 netrin receptor C [Source:MGI Symbol;Acc:MGI:1095412] |
| Ensembl ID | ENSMUSG00000059921 |
| Bio databases IDs | |
| Aliases | unc-5 netrin receptor C |
| Synonyms | B130051O18RIK, LOC101929250, rcm, UNC5H3, Unc-5 homolog C, unc-5 netrin receptor C |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Unc5c often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Death domain
- Thrombospondin type 1 repeats
- Thrombospondin type 1 domain
- protein kinase binding
- thrombospondin-1 motif
- immunoglobulin domain
- Immunoglobulin I-set domain
- protein binding
- UPA domain
- ZU5 domain
- tubulin binding
- Dcc binding domain
- Immunoglobulin like
- repulsive netrin receptor
- membrane-proximal domain
- Spondin-like TSP1 domain
- Death Domain Superfamily of protein-protein interaction domains
- transmembrane receptor
- netrin receptor
Pathways
Biological processes and signaling networks where the Unc5c gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypocalcemia
- pneumonia
- colorectal cancer
- colorectal carcinomagenesis
- hypertension
- myocardial infarction
- polycystic ovary syndrome
- coronary artery disease
- colorectal carcinoma
- non-insulin-dependent diabetes mellitus
phenotypes
- abnormal blood uric acid level
- decreased spleen weight
- increased prepulse inhibition
- preweaning lethality complete penetrance
- abnormal Purkinje cell morphology
- abnormal cerebellar Purkinje cell layer
- abnormal cerebellar granule layer morphology
- abnormal cerebellar layer morphology
- abnormal cerebellar lobule formation
- abnormal cerebellar molecular layer
- abnormal cerebellum anterior lobe morphology
- abnormal cerebellum development
- abnormal cerebellum external granule cell layer morphology
- abnormal cerebellum morphology
- abnormal cerebellum vermis lobule morphology
- abnormal corpora quadrigemina morphology
- abnormal corticospinal tract morphology
- abnormal epididymal fat pad morphology
- abnormal fat pad morphology
- abnormal gait
- abnormal inferior colliculus morphology
- abnormal innervation pattern to muscle
- abnormal neuronal migration
- abnormal phrenic nerve innervation pattern to diaphragm
- abnormal phrenic nerve morphology
- abnormal posture
- abnormal pyramidal decussation morphology
- abnormal spinal cord dorsal column morphology
- abnormal trochlear nerve morphology
- ataxia
- decreased body size
- decreased body weight
- ectopic Purkinje cell
- ectopic cerebellar granule cells
- head bobbing
- hyperactivity
- increased fluid intake
- increased food intake
- increased inferior colliculus size
- male infertility
- postnatal growth retardation
- preweaning lethality incomplete penetrance
- reduced cerebellar foliation
- small cerebellum
- tremors
role in cell
- growth
- invasion
- apoptosis
- colony formation
- degeneration
- proliferation
- migration
- guidance
- development
- migration by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
- growth cone
- filopodia
- perikaryon
- axons
- dendrites
- axon branches
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Unc5c gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- germ cell programmed cell death
- positive regulation of apoptotic process
- apoptotic process
- axon guidance
- anterior/posterior axon guidance
- positive regulation of reproductive process
- brain development
- positive regulation of developmental process
- regulation of neuron migration
- netrin-activated signaling pathway
Cellular Component
Where in the cell the gene product is active
- growth cone
- dendrite
- filopodium
- neuronal cell body
- synapse
- plasma membrane
- cell surface
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- tubulin binding
- protein binding
- netrin receptor activity
- netrin receptor activity involved in chemorepulsion