Prodh1 Gene Summary [Rat]
Enables amino acid binding activity and proline dehydrogenase activity. Predicted to be involved in proline catabolic process to glutamate and regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway. Predicted to be located in nucleoplasm. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in amino acid metabolic disorder; hyperprolinemia type 1; and schizophrenia 4. Orthologous to human PRODH (proline dehydrogenase 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Prodh1 |
| Official Name | proline dehydrogenase 1 [Source:RGD Symbol;Acc:1590932] |
| Ensembl ID | ENSRNOG00000000281 |
| Bio databases IDs | |
| Aliases | proline dehydrogenase 1 |
| Synonyms | AC007325.2, HSPOX2, LOC102724788, LOC682565, PIG6, POX, Pro-1, PRODH1, proline dehydrogenase, proline dehydrogenase 1, Proline oxidase, TP53I6, Ym24d07 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Prodh1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FAD binding
- proline dehydrogenase
- enzyme
- amino acid binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hyperprolinemia 1
- schizophrenia
- schizophrenia type 4
- global developmental delay with intellectual disability
- survival
- hereditary disorder
- colorectal adenocarcinoma
- colorectal carcinomagenesis
role in cell
- expression in
- contact growth inhibition
- growth
- phosphorylation in
- apoptosis
- proliferation
- production in
- migration
- autophagy by
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- mitochondrial fraction
- intracellular membrane-bounded organelle
- Mitochondria
- mitochondrial matrix
- mitochondrial inner membrane
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Prodh1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- 4-hydroxyproline catabolic process
- proline metabolic process
- induction of apoptosis by oxidative stress
- proline catabolic process
- proline catabolic process to glutamate
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
- intracellular membrane-bounded organelle
- mitochondrion
- mitochondrial inner membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- FAD binding
- proline dehydrogenase activity